Post-Doctoral Fellow

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Post-Doctoral Fellow

Ivashkiv Lab

Full-Time

Overview:

 A Postdoctoral Fellow position in the Research Institute is available in the laboratory of Dr. Lionel B. Ivashkiv, at the   Hospital for Special Surgery affiliated with Weill Cornell Medicine in New York City. The main focus of the lab is to     investigate cytokines, trained immunity, and the molecular, cellular and epigenetic mechanisms underlying the     pathogenesis of inflammatory and musculoskeletal diseases. The lab uses state-of-the-art molecular and genomic   approaches, preclinical models, and patient-derived samples.

Responsibilities:

The fellow will be responsible for working in conjunction with Dr. Ivashkiv to develop and carry out scientific projects related to cytokine crosstalk in inflammation and inflammatory and musculoskeletal diseases. She/he will design and perform experiments that utilize molecular, cellular and genetic techniques to answer questions about mechanisms that regulate cytokine production during inflammation. The projects will involve studying primary human macrophages from blood or synovium of healthy subjects or rheumatoid arthritis patients, and preclinical models of arthritis and inflammation, to understand signaling pathways and epigenetic mechanisms that control the expression of disease-causing genes. She/he will independently design and perform experiments that are expected to lead to first author peer-reviewed publications.

The fellow will contribute to the preparation of manuscripts and grant applications, will publish their work in high quality and impact international peer-reviewed journals, and will assist with training and supervision of technical personnel and students. She/he will maintain accurate and detailed records and databases of all laboratory work and experiments. The fellow will present at lab meetings and represent the lab at other local, national, and international forums.

The fellow will be supervised by the laboratory PI Dr. Lionel Ivashkiv. The PI will have biweekly formal meetings with the fellow to discuss the experiments, data, and plans in addition to supervision and mentoring during lab meetings and informal meetings to discuss data or troubleshoot problems.

Minimum Job Requirements:

Successful candidates will have a Ph.D. or M.D. degree. The fellow will demonstrate a high level of understanding of immunology, genomics, and inflammatory diseases, will apply advanced concepts from the scientific literature to their work, and will have the potential to develop into an independent scientist. It is expected that this work will provide insights about new therapeutic approaches in inflammatory diseases. This position provides opportunities for individuals interested in developing strong basic and translational research experience. High level of motivation and independence and the ability to think critically are expected. PhD candidates expected to graduate soon are also encouraged to apply.

Skills:

For bench work, the candidate will have experience performing experiments isolating and analyzing proteins and nucleic acids from primary human cells and clinical samples from patients with autoimmune diseases, including CRISPR-Cas9-mediated gene editing. For genomics, the candidate will have sufficient skills to utilize advanced genome-wide techniques that involve high throughput next generation sequencing including RNA-seq, ChIP-seq and ATAC-seq. For computational biology, the candidate will use computational pipelines to manage genomic data and downstream computational and statistical packages to analyze these data, including STAR, HTseq, HTcounts, CuffDiff, DEseq, EDGE-R, and LimmaVoom. 

The Hospital for Special Surgery is embedded in a vibrant research environment encompassing Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and Rockefeller University. Interested applicants should send CV and names of three references to: Dr. Lionel Ivashkiv, Senior Scientist at the Hospital for Special Surgery, 540 East 70th Street, New York, New York 10021, Email: ivashkivl@hss.edu