Postdoctoral Fellow-Arthroplasty Research Lab

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Postdoctoral Fellow

Bostrom Lab

Full-Time

Position Overview:

Postdoctoral Fellow position is available in the Arthroplasty Research Lab of Dr. Mathias Bostrom at Hospital for Special Surgery Research Institute (HSSRI), to study the role of immune cells in successful and failed osseointegration.

Using a set of mouse implant osseointegration models developed by Dr. Xu Yang of the Arthroplasty Research Lab, we have recently demonstrated that LepR+ cells are the origin of peri-implant fibroblasts. The paper reporting this finding has been accepted by Nature Biomedical Engineering. We will now use these models to study the interactions between immune cells and skeletal stem/progenitor cells after implantation. A special focus will be put on the mechanism and consequence of the formation of fibrosis tissue around implant during failed osseointegration. Human macrophages or skeletal stem/progenitors from bone marrow or periprosthetic tissue of patients receiving primary or revision joint replacement surgeries will also be used to direct the design of animal models or confirm the findings from animal models.

Dr. Xu Yang is also collaborating with Dr. Lionel Ivashkiv, a bone immunologist, at HSSRI on a NIH R01 grant to investigate the inflammatory and bone marrow responses that drive osteoclastogenesis, and the feedback mechanisms that suppress the adaptive immune response to periprosthetic joint infection.

The position requires a Ph.D. in Immunology or Molecular Biology, who has direct experience working with immune cells using advanced cellular, molecular, and genomic techniques. This position combines in vivo research with molecular and cellular biology. For in vivo work, the candidate will be capable of assisting animal surgeries and have experience with isolating proteins and nucleic acids from mouse bone and clinical samples from patients receiving joint replacements. For cellular and molecular studies, the candidate will also have experience with flowcytometry, immunofluorescence, cell culture, RT-PCR, and RNA-seq. The candidate is expected to have one or more high quality first author publications on immunology or mouse models of inflammation disease or both. The candidate should be highly motivated and productive and interested in a career in research. Expertise in mouse models for wound healing and/or in working with immune cells in skeletal system would be a plus. The postdoctoral fellow will report directly to Dr. Xu Yang to discuss the experimental plan and research direction in the area of interest and attend the weekly lab meeting with Dr. Bostrom and Dr. Ivashkiv.

Major duties and responsibilities

• Design and execute experimental procedures/protocols in research involving cell and molecular biology techniques, tissue culture, histology and immunological assay, polarizing and fluorescence microscopy, and animal model system including mouse breeding and genotyping.
• Collecting, analyzing and reporting on experimental data to the Principal Investigator on a timely manner.
• Maintain accurate and detailed records and databases of all laboratory work and experiments.
• Apply standard scientific protocols to experiments, research and improve current methods, and develop, set-up, and verify new procedures in the
• Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols for research.
• Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks.
• Timely compile, present and discuss relevant insights about experimental results with Principal Investigator.
• Maintain and monitor proper use of laboratory equipment.
• Troubleshoot and correct erroneous results or problems with laboratory equipment.
• Draft, write, and edit scientific papers, journal articles, abstracts and progress reports related to the work.
• Maintain an integral role in the laboratory's meetings, departmental seminars, presentations, and publications.
• Organization, and recording of research material inventory, and placing order for research reagent in a timely manner
• Completion of all trainings related to work in a timely manner, including C14, animal usage, handling hazardous material, laboratory safety.
• Participate in establishing job requirements and goals; perform duties at the desired level of competency.

 Minimum Job Requirements

• Education/Training: PhD or medical degree
• Experience: 2+ years of experience in basic science research